cellular s-value of beta emitter radionuclide’s determined using geant4 monte carlo toolbox, comparison to mird s-values

Cellular S-value of beta emitter radionuclide’s determined using Geant4 Monte Carlo toolbox, comparison to MIRD S-values

Introduction: Spatial dose distribution around the radionuclides sources is required for optimized treatment planning in radioimmunotherapy. At present, the main source of data for cellular dosimetry is the s-values provided by MIRD. However, the MIRD s-values have been calculated based on analytical formula in which no electrons straggling is taken to account. In this study, we used Geant4-DNA...

Cellular S-value of beta emitter radionuclide’s determined using Geant4 Monte Carlo toolbox, comparison to MIRD S-values

Introduction: Spatial dose distribution around the radionuclides sources is required for optimized treatment planning in radioimmunotherapy. At present, the main source of data for cellular dosimetry is the s-values provided by MIRD. However, the MIRD s-values have been calculated based on analytical formula in which no electrons straggling is taken to account. In this study, we used Geant4-DNA...

Evaluation of cellular S-value of auger electrons emitting 111In radionuclide by Geant4 and its comparison with MCNP5 Monte Carlo codes and MIRD published data

Introduction: Now day Ionizing radiation has found increasing applications in cancer treatment. However, in the treatment different kinds and size of tumors especially metastatic and small size tumors, conventional methods of external radiation therapy are not common. In radionuclide therapy, the use of monoclonal antibodies has made it possible to achieve maximum dose to small size tumor and m...

Dosimetry for Beta-Emitter Radionuclides by Means of Monte Carlo Simulations

Cellular dosimetry of beta emitting radionuclides-antibody conjugates for radioimmunotherapy

Introduction: The choice of optimal radionuclides for radioimmunotherapy depends on several factors, especially the radionuclide and antibody. The dosimetric characteristics of a non-internalizing and an internalizing monoclonal antibody (MAb) labeled with beta emitting radionuclides were investigated. Methods: Using Geant4-DNA Monte Carlo simulation, we ...

Parallel Quasi-Monte Carlo Integration Using (t, s)-Sequences

Currently, the most eeective constructions of low-discrepancy point sets and sequences are based on the theory of (t; m; s)-nets and (t; s)-sequences. In this work we discuss parallelization techniques for quasi-Monte Carlo integration using (t; s)-sequences. We show that leapfrog parallelization may be very dangerous whereas block-based paral-lelization turns out to be robust.